Description

Demelverine is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) with significant importance in therapeutic development. Its value lies in its role as a key building block for synthesizing advanced drug candidates, particularly in the spasmolytic and anticholinergic therapeutic classes. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of specialized medications targeting smooth muscle disorders.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of antispasmodic and anticholinergic active pharmaceutical ingredients (APIs).
• Research & Development: Serves as a key reference standard and starting material in medicinal chemistry for developing new therapeutic agents.
• Bulk Drug Substance: Used in the commercial-scale manufacturing of finished dosage forms under current Good Manufacturing Practice (cGMP) guidelines.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Demelverine
CAS No.	18719-09-0
Molecular Formula	C20H25NO4
Molecular Weight	343.42 g/mol
Synonyms	Demelverine; 1-Methyl-4-piperidyl diphenylacetate; 1-Methyl-4-piperidinol diphenylacetate (ester); 4-(Diphenylacetoxy)-1-methylpiperidine; NSC 113986; Diphenylacetic acid 1-methyl-4-piperidyl ester
EINECS	Contact for details

Quality Control

Our Demelverine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and strength, consistent with ICH Q7 guidelines for active pharmaceutical ingredients. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to ensure full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.