Description

1,2-Distearoyl-Sn-Glycero-3-Phosphocholine Dihydrate is a high-purity, synthetic phospholipid that serves as a critical building block for advanced lipid-based formulations. Its consistent molecular structure is essential for creating stable, reproducible, and biocompatible lipid bilayers and vesicles. This product is vital for research and development teams in the pharmaceutical, biotechnology, and advanced material science sectors who require a reliable and well-characterized lipid source for applications such as drug delivery systems and membrane model studies.

Application

• Liposome and Nanoparticle Formulation: A primary component for constructing stable, uniform liposomes used in drug delivery, vaccine adjuvants, and diagnostic imaging agents.
• Biomimetic Membrane Research: Used to create model cell membranes (e.g., supported lipid bilayers, vesicles) for studying membrane protein interactions, permeability, and cellular processes.
• Pharmaceutical Excipient: Employed as a structural and functional excipient in lipid nanoparticle (LNP) formulations for mRNA and siRNA therapeutics.
• Cosmetic and Dermal Delivery Systems: Incorporated into niosomes and other vesicular systems for the controlled release of active ingredients in skincare products.
• Biophysical and Analytical Standards: Serves as a high-purity reference standard in chromatography (HPLC, LC-MS) and spectroscopy for quality control and method development.
• Cryopreservation Media: Used as a protective agent in cryopreservation solutions for cells and tissues.

Basic Information

Product Name	1,2-Distearoyl-Sn-Glycero-3-Phosphocholine Dihydrate
CAS No.	18603-43-5
Molecular Formula	C44H90NO8P • 2H2O
Molecular Weight	832.15 g/mol (for dihydrate)
Synonyms	DSPC; 1,2-Distearoylphosphatidylcholine; Distearoylphosphatidylcholine; Distearoyl Lecithin; 1,2-Di-O-octadecanoyl-sn-glycero-3-phosphocholine; 3-sn-Phosphatidylcholine, 1,2-distearoyl-; L-α-Phosphatidylcholine, distearoyl-; (2R)-2,3-Bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
EINECS	242-428-4

Quality Control

Our 1,2-Distearoyl-Sn-Glycero-3-Phosphocholine Dihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, TLC for lipid profile, and specific tests for residual solvents and water content, to ensure it meets stringent specifications for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	4.0 - 6.0 % (corresponding to dihydrate)
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Phosphorus Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.