Description

Bis(Trimethylsilyl)=(Phenylmethyl) Phosphonate is a specialized organosilicon phosphonate reagent used in advanced synthetic chemistry. This compound is valued for its role as a key intermediate and protecting group reagent in the synthesis of complex organic molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing phosphonate esters and other sensitive organophosphorus compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing phosphonate or phosphate ester functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, insecticides, and plant growth regulators that incorporate phosphonate groups.
• Peptide & Nucleotide Chemistry: Serves as a protecting group reagent for phosphate and phosphonate moieties during the synthesis of modified oligonucleotides and phosphopeptides.
• Material Science Precursor: Employed in the development of flame retardants, specialty polymers, and metal-organic frameworks (MOFs) where phosphorus-based ligands are required.
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions, such as the Hirao reaction, for forming carbon-phosphorus bonds.
• Laboratory Reagent: Used as a silylating and phosphorylating agent in research-scale organic synthesis for introducing the (phenylmethyl) phosphonate group under mild conditions.

Basic Information

Product Name	Bis(Trimethylsilyl)=(Phenylmethyl) Phosphonate
CAS No.	18406-56-9
Molecular Formula	C13H25O3PSi2
Molecular Weight	316.48 g/mol
Synonyms	Benzylphosphonic Acid Bis(trimethylsilyl) Ester; (Benzyloxy)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-(Phenylmethyl)-, Bis(trimethylsilyl) Ester; P-Benzylphosphonic Acid Bis(trimethylsilyl) Ester; TMS-Benzyl Phosphonate; Bis(TMS) Benzyl Phosphonate; Benzyl Bis(trimethylsilyl) Phosphonate
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)=(Phenylmethyl) Phosphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.