Description

Dihydropicrotoxinin CAS NO 17617-46-8 is a specialized neuroactive chemical compound derived from picrotoxin, serving as a key intermediate and reference standard in advanced research. Its primary value lies in its utility for studying GABA-A receptor antagonism and related neurological pathways, providing critical insights for neuropharmacology. This product is essential for research institutions, pharmaceutical R&D laboratories, and chemical manufacturers focused on developing or analyzing central nervous system (CNS) active agents and their mechanisms.

Application

• Neurological Research: Acts as a crucial reference standard and tool compound for investigating GABA-A receptor function and modulation.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the synthesis and quality control of neuropharmacological agents.
• Academic Studies: Used in university and institutional labs for fundamental research on convulsants, neurotoxins, and inhibitory neurotransmission.
• Biochemical Assays: Employed in in vitro screening assays to evaluate the activity of potential therapeutic compounds targeting ion channels.
• Chemical Synthesis: Functions as a sophisticated building block for the preparation of more complex, structurally related compounds for biological evaluation.
• Toxicology & Safety Testing: Utilized as a benchmark substance in studies assessing the effects and mechanisms of neurotoxic agents.

Basic Information

Product Name	Dihydropicrotoxinin
CAS No.	17617-46-8
Molecular Formula	C15H18O6
Molecular Weight	294.30 g/mol
Synonyms	Dihydro-picrotoxinin; 6,7,8,9-Tetrahydro-4a,7,9-trihydroxy-2,6-methano-2H-1-benzoxocin-3(4H)-one; Picrotoxinin, dihydro-; NSC 169854; (1R,2S,5S,6R,8S,9S,10R)-5,6,9,10-Tetrahydro-8,10-dihydroxy-2,5-methano-2H-1-benzoxocine-3,4(8H)-dione
EINECS	Contact for details

Quality Control

Our Dihydropicrotoxinin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatography. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the original container has been opened. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.