Description

Picrotoxinin CAS NO 17617-45-7 is a potent neuroactive diterpenoid compound, serving as the primary active component of picrotoxin. This high-purity reference standard is critical for ensuring accurate research and development outcomes in neuroscience and pharmacology. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors who require a reliable and well-characterized compound for neurobiological studies, receptor characterization, and analytical method development.

Application

• Neuroscience Research: Used as a selective, non-competitive antagonist for GABAA receptors to study inhibitory neurotransmission, neuronal excitability, and convulsant mechanisms.
• Pharmacological Reference Standard: Serves as a critical analytical standard in HPLC, LC-MS, and NMR for the identification and quantification of picrotoxin and its components in research samples.
• Toxicology Studies: Employed in studies investigating the mechanisms of action of central nervous system (CNS) stimulants and convulsants.
• Drug Discovery & Development: Utilized in high-throughput screening (HTS) assays to identify novel modulators of the GABAergic system for potential therapeutic applications.
• Biochemical Assays: Applied in in vitro electrophysiology and binding assays to characterize the function and pharmacology of chloride ion channels.
• Academic & Educational Use: A key reagent for university laboratories and teaching institutions for advanced studies in neurochemistry and molecular pharmacology.

Basic Information

Product Name	Picrotoxinin
CAS No.	17617-45-7
Molecular Formula	C15H16O6
Molecular Weight	292.28 g/mol
Synonyms	Cocculin; Picrotoxin component; Picrotoxin, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8S*,8aR*,8balpha))-Isomer; (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8S*,8aR*,8balpha))-2,3,6,6a,7,8,8a,8b-Octahydro-1a,6beta-dihydroxy-1a-methyl-8-(1-methylethenyl)-oxireno(4,5)cyclopenta(1,2-c)furan-3(1H)-one; Anamirtin; 3,6-Methanoisobenzofuran-8(3H)-one, 1a,2,3,6,6a,7,8,8b-octahydro-1a,6-dihydroxy-1a-methyl-8-(1-methylethenyl)-, (1aR,3R,6S,6aR,8S,8aR,8bR)-rel-
EINECS	241-581-9

Quality Control

Our Picrotoxinin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR) and purity determination by HPLC. A detailed Certificate of Analysis (COA) documenting identity, purity, and related substances is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.