Description

2-Piperazinecarboxylic Acid, 1,4-Bis(Phenylmethyl)-Methyl Ester,Dihydrochloride is a high-purity chemical intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a protected piperazine derivative, offering a versatile scaffold for constructing complex molecules with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) due to its modifiable piperazine core.
• Peptidomimetic Synthesis: Acts as a precursor for creating non-peptide compounds that mimic the structure and function of peptides.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or metal complexes.
• Academic and R&D Laboratories: Utilized in fundamental organic synthesis research and method development.
• Custom Synthesis Projects: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	2-Piperazinecarboxylic Acid, 1,4-Bis(Phenylmethyl)-Methyl Ester,Dihydrochloride
CAS No.	17532-21-7
Molecular Formula	C21H26N2O2 · 2HCl
Molecular Weight	419.37 g/mol (for the dihydrochloride salt)
Synonyms	1,4-Dibenzyl-2-(methoxycarbonyl)piperazine Dihydrochloride; Methyl 1,4-Dibenzyl-2-piperazinecarboxylate Dihydrochloride; 1,4-Dibenzylpiperazine-2-carboxylic Acid Methyl Ester Dihydrochloride; 2-Carbomethoxy-1,4-dibenzylpiperazine Dihydrochloride; NSC 163181; 1,4-Dibenzyl-2-(methoxycarbonyl)piperazine Dihydrochloride Salt; Piperazine-2-carboxylic acid, 1,4-bis(phenylmethyl)-, methyl ester, dihydrochloride
EINECS	Contact for details

Quality Control

Our 2-Piperazinecarboxylic Acid, 1,4-Bis(Phenylmethyl)-Methyl Ester,Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request, providing full traceability and compliance assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.