Description

1-Acetyl-4-Oxonipecotic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a well-defined heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Organic Synthesis Building Block: Used in research and development for constructing complex piperidine and piperazine-based molecular frameworks.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and manufacturing of target APIs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations specializing in custom synthesis and development.

Basic Information

Product Name	1-Acetyl-4-Oxonipecotic Acid Methyl Ester
CAS No.	17038-83-4
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	Methyl 1-acetyl-4-oxopiperidine-3-carboxylate; 4-Oxo-1-piperidineacetic acid, α-carboxy-, methyl ester, 1-acetyl-; 1-Acetyl-4-oxo-3-piperidinecarboxylic acid methyl ester; 3-Carbomethoxy-1-acetyl-4-piperidone; Methyl 1-acetyl-4-oxonipecotate; 1-Acetyl-4-oxo-piperidine-3-carboxylic acid methyl ester; 1-Acetyl-4-piperidone-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-Acetyl-4-Oxonipecotic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.