Description

cis-5-Hydroxypiperidine-2-Carboxylic Acid is a high-purity, multifunctional chiral building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a hydroxyl group on a piperidine scaffold, makes it a versatile intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), chiral ligands, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel APIs, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Chiral Ligand & Catalyst Precursor: Used in the synthesis of asymmetric catalysts and ligands for enantioselective synthesis.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and plant growth regulators requiring specific stereochemistry.
• Peptidomimetics & Constrained Amino Acids: Incorporated into peptide backbones to create conformationally restricted analogs with enhanced stability and biological activity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical purity and reliable supply.

Basic Information

Product Name	cis-5-Hydroxypiperidine-2-Carboxylic Acid
CAS No.	17027-45-1
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(2S,5R)-5-Hydroxypiperidine-2-carboxylic acid; (2S,5R)-5-Hydroxy-2-piperidinecarboxylic acid; cis-5-Hydroxy-D-proline; 5-Hydroxypipecolic acid (cis isomer); L-5-Hydroxypipecolic acid; (2S,5R)-5-Hydroxy-2-piperidinecarboxylic acid; 5-Hydroxy-L-pipecolic acid; (2S,5R)-5-Hydroxypipecolic acid
EINECS	Contact for details

Quality Control

Our cis-5-Hydroxypiperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.