Description

(3As)-3Aβ,4,5,5A,6,7,9Aβ,9Bα-Octahydro-6β-Hydroxy-5Aα,9-Dimethyl-3-Methylenenaphtho[1,2-B]Furan-2(3H)-One is a complex, high-purity sesquiterpene lactone derivative with a defined stereochemistry. This compound is valued for its unique molecular scaffold, which serves as a critical intermediate in advanced organic synthesis and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of novel therapeutic agents, particularly in oncology and anti-inflammatory drug discovery.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its complex terpenoid structure for bioactivity.
• Natural Product Synthesis: Acts as a sophisticated precursor in the total synthesis of complex natural products and their analogs for biological evaluation.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological studies in organic chemistry and catalysis.
• Process Chemistry Development: Applied in scaling up synthetic routes and optimizing manufacturing processes for complex molecules.

Basic Information

Product Name	(3As)-3Aβ,4,5,5A,6,7,9Aβ,9Bα-Octahydro-6β-Hydroxy-5Aα,9-Dimethyl-3-Methylenenaphtho[1,2-B]Furan-2(3H)-One
CAS No.	16886-36-5
Molecular Formula	C15H20O3
Molecular Weight	248.32 g/mol
Synonyms	6β-Hydroxy-5α,9-dimethyldecahydro-3-methylenenaphtho[1,2-b]furan-2(3H)-one; Alantolactone Isomer; Isoalantolactone (related); Helenin derivative; Sesquiterpene lactone, octahydro-6-hydroxy-5,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2-one; (3aR,5aR,6R,9aR,9bS)-6-Hydroxy-5a,9-dimethyldecahydro-3-methylenenaphtho[1,2-b]furan-2-one; 16886-36-5; Inula helenium lactone derivative.
EINECS	Contact for details

Quality Control

Our (3As)-3Aβ,4,5,5A,6,7,9Aβ,9Bα-Octahydro-6β-Hydroxy-5Aα,9-Dimethyl-3-Methylenenaphtho[1,2-B]Furan-2(3H)-One is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.