Description

5-Methyl-3-Phenylisoxazole-4-Carbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its core value lies in its role as a versatile acylating agent, enabling the efficient construction of complex heterocyclic amides and esters. This compound is critically needed by research and development laboratories, pharmaceutical manufacturers, and agrochemical producers for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that incorporate the isoxazole moiety for enhanced biological activity.
• Material Science Research: Serves as a precursor for functional polymers and advanced organic materials requiring specific heterocyclic units.
• Peptide Mimetics & Conjugation: Employed in the creation of peptide analogs and for the conjugation of bioactive molecules to carriers or probes.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and for producing custom compounds for biological screening.

Basic Information

Product Name	5-Methyl-3-Phenylisoxazole-4-Carbonyl Chloride
CAS No.	16883-16-2
Molecular Formula	C11H8ClNO2
Molecular Weight	221.64 g/mol
Synonyms	5-Methyl-3-phenyl-4-isoxazolecarbonyl chloride; 4-Isoxazolecarbonyl chloride, 5-methyl-3-phenyl-; 3-Phenyl-5-methylisoxazole-4-carbonyl chloride; 5-Methyl-3-phenyl-1,2-oxazole-4-carbonyl chloride; 16883-16-2; 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Methyl-3-Phenylisoxazole-4-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical and advanced R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition from moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.