Description

4-Hydroxyphenylbutazone is a phenylbutazone derivative, recognized for its role as a key intermediate in pharmaceutical synthesis. This compound matters for its utility in the research and development of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel anti-inflammatory and analgesic drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new phenylbutazone analogs with improved efficacy and safety profiles.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Employed in in-vitro studies to investigate cyclooxygenase (COX) inhibition mechanisms and related biochemical pathways.
• Fine Chemical Synthesis: Utilized as a precursor for the preparation of more complex, functionally specialized organic molecules.

Basic Information

Product Name	4-Hydroxyphenylbutazone
CAS No.	16860-43-8
Molecular Formula	C₁₉H₂₀N₂O₂
Molecular Weight	308.38 g/mol
Synonyms	4-Hydroxyphenylbutazone; 4-(4-Hydroxyphenyl)-1,2-diphenyl-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(4-hydroxyphenyl)-3,5-pyrazolidinedione; Oxyphenbutazone Impurity; 4'-Hydroxyphenylbutazone; 4-HPB; 4-Hydroxy Phenylbutazone; 4-Hydroxy-1,2-diphenyl-4-(4-hydroxyphenyl)-3,5-pyrazolidinedione
EINECS	240-877-7

Quality Control

Our 4-Hydroxyphenylbutazone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.