Description

Difluorocarbamic Acid Chloride is a highly reactive organofluorine building block, serving as a key intermediate for the introduction of the difluorocarbamoyl group. Its value lies in enabling the synthesis of complex molecules with enhanced metabolic stability and lipophilicity, crucial for advanced material and pharmaceutical research. This compound is essential for R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty chemical industries seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Critical for synthesizing fluorinated active pharmaceutical ingredients (APIs) and prodrugs, particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where fluorine incorporation improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or modifying agent for creating fluorinated polymers, coatings, and surfactants with unique surface properties.
• Organic Synthesis Reagent: A versatile reagent for peptide coupling and amide bond formation under mild conditions in complex molecule assembly.
• Ligand and Catalyst Development: Employed in the design of novel fluorinated ligands for catalysis and molecular recognition applications.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) imaging agents, though requiring specialized handling.

Basic Information

Product Name	Difluorocarbamic Acid Chloride
CAS No.	16847-30-6
Molecular Formula	CClF2NO
Molecular Weight	115.48 g/mol
Synonyms	Carbamic chloride, N,N-difluoro-; Difluorocarbamoyl chloride; N,N-Difluorocarbamoyl chloride; Chlorocarbonyl difluoroamine; Difluoroaminocarbonyl chloride; N,N-Difluorocarbamic acid chloride; Carbonochloridic acid, difluoro-
EINECS	Contact for details

Quality Control

Our Difluorocarbamic Acid Chloride is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing including GC, NMR, and titration to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) and away from moisture, strong bases, and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.