Description

Iodoglibenclamide is a halogenated derivative of the well-known sulfonylurea drug, glibenclamide. This compound is primarily valued as a high-purity pharmaceutical reference standard and a critical chemical intermediate in advanced research and synthesis. It is essential for researchers and manufacturers in the pharmaceutical and life science sectors who require precise, well-characterized materials for method development, quality control, and novel drug discovery programs.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of glibenclamide and related compounds in pharmacopeial testing (e.g., USP, EP).
• Metabolic Research: Serves as a tool compound in studies investigating the metabolism, pharmacokinetics, and structure-activity relationships (SAR) of sulfonylurea drugs.
• Chemical Synthesis Intermediate: Acts as a key building block for the research-scale synthesis of novel glibenclamide analogs and labeled derivatives for tracer studies.
• Analytical Method Development: Employed in HPLC, LC-MS, and GC-MS method development and validation as a known analyte to ensure system suitability and accuracy.
• Quality Control & Assurance: Critical for in-house QC laboratories to verify the identity and purity of glibenclamide API (Active Pharmaceutical Ingredient) and finished dosage forms.

Basic Information

Product Name	Iodoglibenclamide
CAS No.	16789-77-8
Molecular Formula	C23H28ClIN3O5S
Molecular Weight	620.90 g/mol
Synonyms	5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-3-iodobenzamide; 1-[[4-[2-(5-Chloro-2-methoxy-3-iodobenzamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea; Iodinated Glibenclamide; Iodo-Glibenclamide; Iodoglyburide
EINECS	Contact for details

Quality Control

Our Iodoglibenclamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, related substance analysis, and identity confirmation (IR, MS) to ensure it meets stringent specifications for research and reference standard use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.