Description

Naltrexone Hydrochloride is a potent opioid receptor antagonist used primarily in pharmaceutical formulations. This compound is critical for the treatment of alcohol and opioid dependence, offering a non-addictive therapeutic pathway. It is a key active pharmaceutical ingredient (API) demanded by pharmaceutical manufacturers, research institutions, and compounding facilities for the production of tablets, implants, and other dosage forms.

Application

• Primary Active Pharmaceutical Ingredient (API) in medications for alcohol dependence.
• Core component in opioid addiction treatment drugs (e.g., oral tablets, extended-release implants).
• Research chemical in neuropharmacology and addiction studies.
• Used in the development and production of combination therapies.
• Reference standard in analytical laboratories for quality control and method validation.
• Starting material for further chemical synthesis and derivative development.

Basic Information

Product Name	Naltrexone Hydrochloride
CAS No.	16676-29-2
Molecular Formula	C20H23NO4 • HCl
Molecular Weight	377.86 g/mol (as hydrochloride)
Synonyms	Naltrexone HCl; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride; EN-1639A; UM-792; Nalorex; Depade; ReVia; Vivitrol (brand name for depot formulation); (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
EINECS	240-740-6

Quality Control

Our Naltrexone Hydrochloride is manufactured under strict quality management systems. We offer material that can meet various pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.