Description

Cyclopropanecarbonyl Chloride,1-Methyl- CAS NO 16480-05-0 is a highly reactive and versatile acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the sterically constrained and pharmacologically interesting 1-methylcyclopropanecarbonyl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the 1-methylcyclopropane scaffold to modulate biological activity and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the cyclopropane ring contributes to unique biological profiles.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and polymerization processes.
• Material Science Research: Acts as a monomer or modifying agent in the synthesis of polymers with specific thermal or mechanical properties.
• Peptide & Protein Modification: Utilized for the acylation of amino groups in peptides or proteins to study structure-activity relationships or create bioconjugates.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride,1-Methyl-
CAS No.	16480-05-0
Molecular Formula	C5H7ClO
Molecular Weight	118.56 g/mol
Synonyms	1-Methylcyclopropanecarbonyl chloride; 1-Methylcyclopropanoyl chloride; 1-Methylcyclopropanecarboxylic acid chloride; (1-Methylcyclopropyl)carbonyl chloride; α-Methylcyclopropanecarbonyl chloride; Cyclopropanecarboxylic acid, 1-methyl-, chloride; 1-Methylcyclopropylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride,1-Methyl- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (IR, NMR), to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality systems are designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and highly volatile. Keep away from heat, sparks, open flames, and strong bases. Containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to minimize evaporation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (Karl Fischer)	≤ 0.5%
Density (at 20°C)	~1.12 g/cm³
Boiling Point	~125-130 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.