Description

Niometacin is a non-steroidal anti-inflammatory drug (NSAID) derivative, specifically a glycinamide of indomethacin, known for its potent pharmacological activity. This compound is valued for its targeted anti-inflammatory and analgesic properties, offering a refined therapeutic profile for advanced research and development. It serves as a critical intermediate and active ingredient for pharmaceutical manufacturers and research institutions focused on developing novel NSAID formulations and studying inflammatory pathways.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced non-steroidal anti-inflammatory drugs (NSAIDs) and related therapeutic agents.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research for developing new analgesic and anti-inflammatory medications.
• Biochemical Research: Employed in laboratory studies to investigate cyclooxygenase (COX) enzyme inhibition mechanisms and inflammatory mediator pathways.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and compound identification.
• Veterinary Medicine Development: Applied in the R&D of anti-inflammatory treatments for animal health applications.

Basic Information

Product Name	Niometacin
CAS No.	16426-83-8
Molecular Formula	C21H21ClN2O4
Molecular Weight	400.86 g/mol
Synonyms	N-[(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetyl]glycine; Indomethacin Glycinamide; CL-846; Niometacine; 2-[[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]acetic acid; N-(2-{1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}-2-oxoethyl)glycine; Glycine, N-[2-[1-[(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]-
EINECS	Contact for details

Quality Control

Our Niometacin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and spectroscopy, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container in a well-ventilated area and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.