Description

1-(3,5-Bistrifluoromethylphenyl)-Piperazine is a high-value, fluorinated aromatic piperazine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring electron-withdrawing trifluoromethyl groups, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of receptor antagonists, kinase inhibitors, and central nervous system (CNS) active drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand & Catalyst Development: Employed in organometallic chemistry and catalysis research due to its ability to act as a chelating or modifying ligand.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and advanced materials requiring fluorinated aromatic components.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	1-(3,5-Bistrifluoromethylphenyl)-Piperazine
CAS No.	16172-96-6
Molecular Formula	C12H10F6N2
Molecular Weight	296.21 g/mol
Synonyms	1-[3,5-Bis(trifluoromethyl)phenyl]piperazine; 3,5-Bis(trifluoromethyl)phenylpiperazine; 1-(3,5-Bis(trifluoromethyl)phenyl)piperazine; Piperazine, 1-[3,5-bis(trifluoromethyl)phenyl]-; 16172-96-6; 3,5-Bis(trifluoromethyl)-1-piperazinobenzene; 1-(3,5-Di(trifluoromethyl)phenyl)piperazine
EINECS	Contact for details

Quality Control

Every batch of 1-(3,5-Bistrifluoromethylphenyl)-Piperazine is produced under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and GC-MS to verify identity, purity, and impurity profiles. Our quality commitment ensures material traceability and consistency, supporting your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.