Description

(R)-Phenoxybenzamine Hydrochloride CAS NO 16053-59-1 is the single enantiomer form of the potent, irreversible α-adrenergic receptor antagonist. This high-purity chiral compound is critical for advanced pharmacological research and development, offering precise stereochemical control for studying receptor mechanisms and developing targeted therapies. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on cardiovascular and urological drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Mechanistic Pharmacological Research: Essential tool compound for in vitro and ex vivo studies investigating the role of α-adrenergic receptors in vascular tone, smooth muscle contraction, and neurotransmission.
• Preclinical Drug Development: Employed in animal models to evaluate the therapeutic potential of α-blockade for conditions like hypertension, benign prostatic hyperplasia (BPH), and pheochromocytoma.
• Chiral Intermediate Synthesis: Serves as a key building block in the asymmetric synthesis of more complex molecules targeting adrenergic pathways.
• Biochemical Assay Development: Used to create assay controls and standards in high-throughput screening (HTS) campaigns for discovering new receptor modulators.
• Academic Teaching & Research: Utilized in university laboratories for graduate-level instruction and research in medicinal chemistry and pharmacology.

Basic Information

Product Name	(R)-Phenoxybenzamine Hydrochloride
CAS No.	16053-59-1
Molecular Formula	C18H22ClNO2 • HCl
Molecular Weight	340.29 g/mol
Synonyms	(R)-Phenoxybenzamine HCl; (R)-N-Benzyl-N-(2-chloroethyl)-1-phenoxy-2-propanamine Hydrochloride; (R)-N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine Hydrochloride; (R)-Dibenzyline; (R)-POB HCl; (R)-Enantiomer of Phenoxybenzamine Hydrochloride; (R)-N-Phenoxyisopropyl-N-benzyl-β-chloroethylamine Hydrochloride; Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride, (R)-
EINECS	Contact for details

Quality Control

Our (R)-Phenoxybenzamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.