Description

Bis(3,5-Bis(trifluoromethyl)phenyl)phosphine oxide is a high-value, fluorinated organophosphorus compound characterized by its electron-deficient aromatic rings. This compound matters as a versatile and highly effective ligand precursor in transition metal catalysis, particularly for cross-coupling reactions demanding high activity and stability. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel synthetic routes and manufacturing active ingredients.

Application

• As a precursor to Buchwald-type biarylphosphine ligands for palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, amination).
• As a ligand in metal-catalyzed processes requiring electron-poor, sterically demanding phosphines for challenging substrate couplings.
• In the synthesis of active pharmaceutical ingredients (APIs) and complex organic intermediates where traditional ligands fail.
• For research and development of new catalytic systems in academic and industrial laboratories.
• In the preparation of specialty polymers and advanced materials where fluorinated phosphine oxides act as modifiers or additives.
• As a key intermediate for synthesizing more complex, tailored phosphine ligands and metal complexes.

Basic Information

Product Name	Bis(3,5-Bis(trifluoromethyl)phenyl)phosphine Oxide
CAS No.	15979-14-3
Molecular Formula	C₁₆H₆F₁₂OP
Molecular Weight	530.18 g/mol
Synonyms	Bis[3,5-bis(trifluoromethyl)phenyl]phosphine oxide; [3,5-Bis(trifluoromethyl)phenyl]phosphine oxide, bis-; Tris(3,5-bis(trifluoromethyl)phenyl)phosphine oxide (common misnomer); Phosphine oxide, bis[3,5-bis(trifluoromethyl)phenyl]-; Ligand precursor S-Phos type (fluorinated analog); DTBM-Phosphine oxide precursor; Electron-deficient biarylphosphine ligand precursor.
EINECS	Contact for details

Quality Control

Our Bis(3,5-Bis(trifluoromethyl)phenyl)phosphine oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for catalytic applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to maintain optimal purity and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.