Description

Norketobemidone is a synthetic opioid analgesic compound of significant interest in pharmacological research. Its primary value lies in its role as a key intermediate and reference standard for the study of opioid receptor activity and analgesic mechanisms. This compound is essential for research and development laboratories in the pharmaceutical and life sciences sectors, particularly those focused on neuropharmacology, pain management research, and forensic toxicology.

Application

• Pharmacological Research: Used as a reference standard in studies investigating the structure-activity relationships (SAR) of opioid analgesics.
• Analytical Chemistry: Serves as a critical certified reference material (CRM) for method development and validation in analytical laboratories.
• Forensic Science: Employed as an analytical standard for the identification and quantification of related substances in forensic toxicology.
• Biochemical Assays: Utilized in in vitro assays to study binding affinity and functional activity at opioid receptors (e.g., μ, κ).
• Pharmaceutical Development: Acts as a chemical intermediate or a precursor in the synthesis of novel therapeutic agents for research purposes.

Basic Information

Product Name	Norketobemidone
CAS No.	15847-72-0
Molecular Formula	C₁₅H₂₁NO₂
Molecular Weight	247.33 g/mol
Synonyms	1-Methyl-4-(3-hydroxyphenyl)-4-piperidinol; Nor-Ketobemidone; Desmethylketobemidone; 4-(3-Hydroxyphenyl)-1-methyl-4-piperidinol; NSC 168607; 1-Methyl-4-(m-hydroxyphenyl)-4-piperidinol
EINECS	Contact for details

Quality Control

Our Norketobemidone is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant Good Manufacturing Practice (GMP) principles for active pharmaceutical ingredients (APIs) and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.