Description

(4R-Cis)-4,4A,5,6,7,8-Hexahydro-4,4A-Dimethyl-6-(1-Methylethylidene)Naphthalen-2(3H)-One is a high-purity, stereochemically defined ketone derivative of a decalin system, valued for its role as a key chiral intermediate in complex organic syntheses. Its rigid, fused-ring structure and specific stereochemistry make it a critical building block for constructing molecules with precise three-dimensional architecture. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of bioactive natural products and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug candidates, especially those with steroid-like or terpenoid frameworks.
• Fragrance & Flavor Chemistry: Serves as a precursor for the development of novel, high-value aroma chemicals with unique olfactory properties derived from its decalin core.
• Agrochemical Research: Used in the design and synthesis of new active ingredients for crop protection, leveraging its complex hydrocarbon skeleton.
• Material Science: Acts as a monomer or building block for specialty polymers and liquid crystals, where its rigid structure imparts desired physical properties.
• Academic & Process Chemistry: Employed in methodological studies for asymmetric synthesis, cyclization reactions, and catalysis research.
• Fine Chemical Synthesis: A versatile intermediate for producing custom-designed molecules for various high-value industrial applications.

Basic Information

Product Name	(4R-Cis)-4,4A,5,6,7,8-Hexahydro-4,4A-Dimethyl-6-(1-Methylethylidene)Naphthalen-2(3H)-One
CAS No.	15764-04-2
Molecular Formula	C15H22O
Molecular Weight	218.33 g/mol
Synonyms	4aR,8aS)-4,4a,5,6,7,8-Hexahydro-4,4a-dimethyl-6-(propan-2-ylidene)naphthalen-2(3H)-one; (4R,4aR,8aS)-4,4a,5,6,7,8-Hexahydro-4,4a-dimethyl-6-(1-methylethylidene)-2(3H)-naphthalenone; 2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethylidene)-, (4R-cis)-; cis-4,4a,5,6,7,8-Hexahydro-4,4a-dimethyl-6-isopropylidene-2(3H)-naphthalenone; Decalinone derivative; Chiral decalone intermediate.
EINECS	Contact for details

Quality Control

Our (4R-Cis)-4,4A,5,6,7,8-Hexahydro-4,4A-Dimethyl-6-(1-Methylethylidene)Naphthalen-2(3H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure consistent stereochemical integrity and chemical purity. Comprehensive Certificates of Analysis (COA) detailing identity, assay, impurity profile, and enantiomeric excess are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.