Description

(S,S)-3-Isopropyl-6-Methylpiperazine-2,5-Dione is a high-purity chiral diketopiperazine derivative, serving as a critical advanced intermediate in modern organic synthesis. Its defined stereochemistry and rigid piperazinedione scaffold make it a valuable building block for constructing complex molecules with specific three-dimensional architectures. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Scaffold: Used to design and synthesize constrained peptide analogs, enhancing metabolic stability and bioavailability in drug discovery.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for developing novel chiral ligands used in enantioselective catalysis.
• Chemical Biology Probe: Employed in academic and industrial research to study enzyme-substrate interactions and protein function.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex, high-value specialty chemicals for advanced material science.

Basic Information

Product Name	(S,S)-3-Isopropyl-6-Methylpiperazine-2,5-Dione
CAS No.	15136-26-2
Molecular Formula	C8H14N2O2
Molecular Weight	170.21 g/mol
Synonyms	(3S,6S)-3-Isopropyl-6-methylpiperazine-2,5-dione; (S,S)-Cyclo(Val-Ala); Cyclo(L-valyl-L-alanyl); L-Valyl-L-alanine anhydride; (S,S)-3-Isopropyl-6-methyl-2,5-piperazinedione; (S,S)-3-Isopropyl-6-methylpiperazine-2,5-dione; Cyclo(Val-Ala) diketopiperazine; DKP-Val-Ala
EINECS	Contact for details

Quality Control

Our (S,S)-3-Isopropyl-6-Methylpiperazine-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.