Description

(3S,6R)-3-Benzyl-6-Methyl-2,5-Piperazinedione is a chiral diketopiperazine derivative, a key structural motif in medicinal chemistry and peptide research. This compound serves as a versatile and high-value pharmaceutical intermediate and building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors seeking to incorporate stereochemically defined piperazinedione scaffolds into their target compounds.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of protease inhibitors, kinase inhibitors, and other novel therapeutic agents.
• Peptidomimetics Research: Used to construct constrained peptide analogs and peptidomimetics to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or template in stereoselective organic synthesis.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme mechanisms and protein-protein interactions.
• Fine Chemical Production: A precursor for the manufacture of specialty chemicals and advanced materials requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable reference standard and starting material in discovery chemistry programs.

Basic Information

Product Name	(3S,6R)-3-Benzyl-6-Methyl-2,5-Piperazinedione
CAS No.	15136-19-3
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	(3S,6R)-3-Benzyl-6-methylpiperazine-2,5-dione; (3S,6R)-3-Benzyl-6-methyl-2,5-diketopiperazine; (3S,6R)-3-Benzyl-6-methyl-2,5-dioxopiperazine; (3S,6R)-3-Benzyl-6-methyl-2,5-piperazinedione; 3-Benzyl-6-methyl-2,5-piperazinedione, (3S,6R)-; Cyclo(L-benzylalanine-D-alanine); DKP derivative; Chiral diketopiperazine
EINECS	Contact for details

Quality Control

Our (3S,6R)-3-Benzyl-6-Methyl-2,5-Piperazinedione is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.