Description

Cholic Acid Ethyl Ester is a high-purity, synthetically derived bile acid derivative, specifically the ethyl ester of cholic acid. This compound is a critical intermediate and research reagent valued for its role in modifying the physicochemical properties of the parent bile acid, enhancing lipophilicity and membrane permeability. It is essential for pharmaceutical R&D, particularly in the development of drug delivery systems, metabolic studies, and as a precursor for more complex bioactive molecules. Industries requiring advanced biochemical synthesis, including pharmaceuticals, life sciences, and specialty chemical manufacturing, rely on its consistent quality.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of more complex bile acid derivatives and prodrugs.
• Biochemical Research: Used as a standard or reagent in studies of lipid metabolism, liver function, and bile acid transport mechanisms.
• Drug Delivery Enhancer: Investigated for its potential to improve the absorption and bioavailability of poorly soluble active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Specialty Chemical Synthesis: Building block for creating surfactants, chiral auxiliaries, and other value-added fine chemicals.

Basic Information

Product Name	Cholic Acid Ethyl Ester
CAS No.	15073-99-1
Molecular Formula	C26H44O5
Molecular Weight	436.63 g/mol
Synonyms	Ethyl Cholate; Cholic Acid Ethyl Ester; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid Ethyl Ester; Ethyl 3α,7α,12α-trihydroxy-5β-cholan-24-oate; Taurocholic Acid Ethyl Ester (common misnomer); CAEE; Cholanoic acid, 3,7,12-trihydroxy-, ethyl ester, (3α,5β,7α,12α)-
EINECS	239-138-3

Quality Control

Our Cholic Acid Ethyl Ester is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support compliance with cGMP and ISO guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.