Description

2-Chloropyrazine is a versatile halogenated heterocyclic building block essential for advanced organic synthesis. Its high reactivity, particularly at the chlorine-substituted position, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of various drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the pyrazine core contributes to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the development of organic electronic materials, such as conductive polymers and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce the pyrazinyl moiety into more complex molecules.
• Nucleophilic Aromatic Substitution: The chlorine atom is readily displaced by various nucleophiles (amines, alkoxides, thiols), enabling rapid diversification.

Basic Information

Product Name	2-Chloropyrazine
CAS No.	14508-49-7
Molecular Formula	C4H3ClN2
Molecular Weight	114.53 g/mol
Synonyms	2-Chloropyrazine; Pyrazine, 2-chloro-; Chloropyrazine; 2-Chloro-1,4-diazine; 2-Chloropyrazine (principal name); 2-Pyrazinyl chloride; NSC 403116; AURORA KA-4413
EINECS	Contact for details

Quality Control

Our 2-Chloropyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile and light-sensitive nature, containers must be kept tightly sealed and away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.