Description

cis-1,3,5-Trimethylpiperidine is a sterically hindered, tertiary amine characterized by its specific stereochemistry and strong basicity. This compound matters as a versatile and highly effective organic base and building block in advanced chemical synthesis, offering advantages in selectivity and reactivity. It is needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from catalysis to the synthesis of complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a hindered amine scaffold.
• Catalyst and Ligand Precursor: Used in the preparation of organocatalysts and as a ligand in metal-catalyzed reactions due to its strong basicity and steric profile.
• Agrochemical Synthesis: Employed in the manufacture of herbicides, fungicides, and plant growth regulators.
• Polymer Additive: Acts as a stabilizer or curing agent in polymer formulations, including epoxies and polyurethanes.
• Corrosion Inhibitor Formulation: Utilized in industrial fluids and coatings for its ability to neutralize acids and form protective films.
• Organic Synthesis Reagent: Serves as a non-nucleophilic base in deprotonation reactions and for the scavenging of acids.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies.

Basic Information

Product Name	cis-1,3,5-Trimethylpiperidine
CAS No.	14446-76-5
Molecular Formula	C8H17N
Molecular Weight	127.23 g/mol
Synonyms	1,3,5-Trimethylpiperidine (cis-); cis-1,3,5-Trimethylpiperazine (common misnomer); 1,3,5-Trimethylhexahydropyridine; cis-TMP; TMP; NSC 163022; Hexahydro-1,3,5-trimethylpyridine
EINECS	Contact for details

Quality Control

Our cis-1,3,5-Trimethylpiperidine is produced under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all commercial quantities and are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is 2-25°C. The product is hygroscopic (moisture-sensitive); keep container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	0.830 - 0.850
Refractive Index (n20D)	1.445 - 1.455

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.