Description

4-Hydroxypipecolic Acid is a non-proteinogenic amino acid derivative featuring a hydroxylated piperidine carboxylic acid structure. This compound serves as a versatile chiral building block and intermediate in advanced organic synthesis, particularly for pharmaceuticals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetics Research: Used to incorporate constrained amino acid motifs into peptide analogs to enhance stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and plant growth regulators.
• Biochemical Research: Employed in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Ligand and Catalyst Development: Utilized to create novel chiral ligands for asymmetric catalysis in fine chemical production.
• Cosmetic Ingredient Synthesis: A potential intermediate for synthesizing active compounds in advanced skincare formulations.

Basic Information

Product Name	4-Hydroxypipecolic Acid
CAS No.	14228-16-1
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	4-Hydroxy-2-piperidinecarboxylic Acid; (2S,4R)-4-Hydroxypipecolic Acid; 4-Hydroxypipecolate; 4-Hydroxy-L-pipecolic Acid; cis-4-Hydroxy-L-pipecolic Acid; 4-Hydroxy-DL-pipecolic Acid; 4-Hydroxy-2-piperidinecarboxylic Acid; 4-Hydroxypipecolic Acid (mixture of isomers)
EINECS	Contact for details

Quality Control

Our 4-Hydroxypipecolic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.