Description

2-Hydroxy-5-Iodobenzoyl Chloride is a versatile and highly reactive aromatic acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual functionality, combining a reactive acid chloride group with a phenolic hydroxyl and an iodine substituent, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for synthesizing complex molecules, active pharmaceutical ingredients (APIs), and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting thyroid hormone receptors or requiring iodinated aromatic scaffolds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators where the iodine moiety imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for creating specialized ligands used in transition metal catalysis and molecular recognition systems.
• Polymer Chemistry: Employed in the synthesis of functionalized monomers and polymers with specific optical or electronic properties.
• Dye and Pigment Manufacturing: Intermediate for producing iodinated xanthene and other complex dye structures.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new chemical entities and reaction methodologies.
• Diagnostic Agent Synthesis: Potential use in creating contrast agents or radiolabeling precursors for medical imaging.

Basic Information

Item	Details
Product Name	2-Hydroxy-5-Iodobenzoyl Chloride
CAS No.	13589-25-8
Molecular Formula	C7H4ClIO2
Molecular Weight	282.46 g/mol
Synonyms	5-Iodo-2-hydroxybenzoyl chloride; 5-Iodosalicyloyl chloride; 2-Hydroxy-5-iodobenzoic acid chloride; 5-Iodo-2-hydroxybenzoic acid chloride; 5-Iodosalicylic acid chloride; 13589-25-8; 5-Iodo-2-hydroxy-benzoyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-5-Iodobenzoyl Chloride is produced and tested under a strict quality management system to ensure consistency and reliability for your critical syntheses. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation excellence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.