Description

β-Amanitin is a highly potent bicyclic octapeptide mycotoxin, a principal component of the deadly amatoxin family found in certain poisonous mushrooms. This compound is of critical importance in biochemical and pharmacological research due to its specific and irreversible inhibition of RNA polymerase II, effectively halting mRNA synthesis. It serves as an indispensable tool for researchers in molecular biology, toxicology, and drug discovery who require a precise biochemical probe to study transcription mechanisms, evaluate hepatotoxicity, and develop potential antidotes.

Application

• Biochemical Research: Used as a selective inhibitor of RNA polymerase II to study eukaryotic transcription, gene expression regulation, and mRNA synthesis pathways.
• Toxicology Studies: Employed as a reference standard and active agent in research investigating the mechanisms of amatoxin poisoning, liver failure (hepatotoxicity), and cellular apoptosis.
• Pharmaceutical Development: Serves as a key compound in screening and developing potential antidotes or therapeutic agents for mushroom poisoning.
• Diagnostic Tool Manufacturing: Utilized in the production of calibration standards and controls for analytical methods (e.g., HPLC-MS, ELISA) designed to detect amatoxins in clinical or forensic samples.
• Cell Biology & Cancer Research: Applied in studies exploring the effects of transcription inhibition on cell cycle progression, signal transduction, and in models for evaluating anti-cancer compounds.

Basic Information

Product Name	β-Amanitin
CAS No.	13567-07-2
Molecular Formula	C39H54N10O14S
Molecular Weight	918.97 g/mol
Synonyms	β-Amanitin; β-Amanitin; Amanitin, β-; (3S,6S,9S,12S,15S,18S,21S,24S,30S,33S)-30-[(1S)-1-Hydroxyethyl]-33-(hydroxymethyl)-3,6,9,12,15,18,21,24-octaazatricyclo[24.6.2.212,15]hexatriaconta-1(33),26,28,30,32-pentaene-2,5,8,11,14,17,20,23,29-nonaone; L-Aspartic acid, L-tryptophyl-6-hydroxy-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl-L-asparaginyl-L-prolyl-; Cyclo(L-asparaginyl-L-tryptophyl-6-hydroxy-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl-L-prolyl-L-2,3-dihydroxyisovaleryl-); Amatoxin
EINECS	Contact for details

Quality Control

Our β-Amanitin is produced and handled under strict quality protocols to ensure the highest standards of purity and consistency for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided, documenting the exact specifications and results. We adhere to relevant quality management standards to guarantee product integrity, traceability, and reliability for our global research and pharmaceutical clients.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is strictly light-sensitive and hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.