Description

(2S,4R)-1,2-Dicarbobenzyloxy-4-Hydroxypyrrolidine is a high-purity chiral pyrrolidine derivative, widely recognized as a key building block in advanced organic synthesis. This compound matters for its crucial role as a versatile intermediate in the production of complex pharmaceutical agents, particularly protease inhibitors and other bioactive molecules. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to enable the synthesis of stereochemically defined targets with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of protease inhibitors, including HIV-1 protease inhibitors and renin inhibitors.
• Peptidomimetics Research: Serves as a constrained proline analogue for constructing novel peptide backbones in drug discovery.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• API Development: A building block in the research and process development of new Active Pharmaceutical Ingredients (APIs) requiring specific (2S,4R) stereochemistry.
• Bioconjugation Chemistry: The protected hydroxyl and amine functionalities allow for selective modification in linker chemistry for bioconjugates.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for exploring structure-activity relationships (SAR) in various therapeutic areas.

Basic Information

Product Name	(2S,4R)-1,2-Dicarbobenzyloxy-4-Hydroxypyrrolidine
CAS No.	13500-53-3
Molecular Formula	C20H21NO6
Molecular Weight	371.39 g/mol
Synonyms	(2S,4R)-1,2-Bis(benzyloxycarbonyl)-4-hydroxypyrrolidine; (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1,2-Dibenzyl Ester; 1,2-Di-Cbz-(2S,4R)-4-hydroxyproline benzyl ester; (2S,4R)-1,2-Di-Cbz-4-hydroxyproline; (2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid Dibenzyl Ester; (2S,4R)-HOP; trans-4-Hydroxy-L-proline derivative (protected)
EINECS	Contact for details

Quality Control

Our (2S,4R)-1,2-Dicarbobenzyloxy-4-Hydroxypyrrolidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.