Description

15(S)-Hetre CAS NO 13222-49-6 is a high-purity, stereospecific hydroxy eicosatetraenoic acid (HETE) derivative, a key intermediate in the synthesis of bioactive lipid mediators. This compound is critical for research and development in inflammatory and cellular signaling pathways due to its specific biological activity. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on eicosanoid research, drug discovery, and the development of analytical standards.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and synthetic intermediate in the study of lipoxygenase pathways, inflammation, and related drug discovery projects.
• Biochemical Assay Development: Used as a precise calibrant and substrate in enzymatic assays to study the activity and inhibition of lipoxygenase enzymes.
• Academic Research: Essential for fundamental studies in cell biology, immunology, and pharmacology to elucidate the role of specific HETE isomers in cellular signaling.
• Analytical Standard Manufacturing: Employed as a high-purity certified reference material (CRM) for the calibration of HPLC, LC-MS, and other analytical instruments in metabolomics and lipidomics.
• Precision Synthesis: Acts as a building block for the stereoselective synthesis of more complex eicosanoids and labeled analogs for tracer studies.

Basic Information

Product Name	15(S)-Hetre
CAS No.	13222-49-6
Molecular Formula	C20H32O3
Molecular Weight	320.47 g/mol
Synonyms	15(S)-HETE; 15S-HETE; (15S)-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic Acid; 15(S)-Hydroxyeicosatetraenoic Acid; 15S-Hydroxy-5,8,11,13-eicosatetraenoic Acid; 15S-HETE-d8 (deuterated analog common name); 15-LOX metabolite
EINECS	Contact for details

Quality Control

Every batch of 15(S)-Hetre is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and stereochemical integrity. Our products undergo rigorous quality testing, including chiral HPLC and spectroscopic analysis, to ensure compliance with research-grade standards. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen), as the compound is easily oxidized. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Enantiomeric Purity (Chiral HPLC)	≥ 98% 15(S)-isomer
Solubility	Soluble in ethanol, DMSO, and dimethyl formamide

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.