Description

2-Chloroisobutyryl Chloride is a highly reactive acyl chloride derivative, primarily valued as a key building block in organic synthesis. Its bifunctional nature, featuring both an acid chloride and a chlorinated alkyl group, makes it an essential reagent for introducing the 2-chloroisobutyryl moiety. This compound is critically important for manufacturers in the pharmaceutical, agrochemical, and polymer industries, where it is used to synthesize active pharmaceutical ingredients (APIs), crop protection agents, and specialized polymer initiators.

Application

• Pharmaceutical Intermediate: A crucial starting material for the synthesis of various active pharmaceutical ingredients (APIs), particularly in the production of β-lactam antibiotics and other heterocyclic compounds.
• Polymer Chemistry: Serves as a key initiator or functionalization agent in Atom Transfer Radical Polymerization (ATRP) and other controlled radical polymerization techniques for creating advanced polymers.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides as a reactive intermediate to build complex molecular structures.
• Peptide Modification: Employed for the acylation of amino groups in peptides and proteins for research and development purposes.
• Organic Synthesis Reagent: Acts as a versatile reagent for acylations and as a precursor for other functionalized isobutyric acid derivatives in fine chemical production.
• Dye and Pigment Manufacturing: Utilized in the synthesis of specialized dyes and organic pigments.

Basic Information

Item	Detail
Product Name	2-Chloroisobutyryl Chloride
CAS No.	13222-26-9
Molecular Formula	C4H6Cl2O
Molecular Weight	141.00 g/mol
Synonyms	2-Chloro-2-methylpropanoyl Chloride; α-Chloroisobutyryl Chloride; 2-Chloroisobutyroyl Chloride; 2-Methyl-2-chloropropionyl Chloride; Isobutyryl Chloride, 2-chloro-; Chloroisobutyryl Chloride; 2-Chloro-2-methylpropionyl Chloride
EINECS	236-188-1

Quality Control

Our 2-Chloroisobutyryl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC or titration and impurity profiling, to ensure it meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) documenting purity, identity, and specific impurity limits are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat, sparks, and open flame. Due to its highly volatile and hygroscopic nature, it is recommended to store under an inert atmosphere (e.g., nitrogen) to maintain product integrity. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Color (APHA)	≤ 50
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.