Description

Benadryl n-Oxide Hydrochloride is a specific chemical derivative of diphenhydramine, a well-known antihistamine. This compound is of significant interest in pharmaceutical research and development, particularly for studying metabolic pathways and synthesizing novel active pharmaceutical ingredients (APIs). It serves as a crucial intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antihistamine derivatives and other therapeutic agents.
• Metabolite Reference Standard: Used in analytical laboratories for the identification and quantification of diphenhydramine metabolites in pharmacokinetic and bioequivalence studies.
• Biochemical Research: Employed in academic and industrial research to investigate the pharmacological and toxicological profiles of diphenhydramine oxidation products.
• Fine Chemical Synthesis: Serves as a specialized reagent for constructing complex molecular architectures in medicinal chemistry programs.
• Quality Control Standard: Utilized as a certified reference material (CRM) to ensure the purity and consistency of pharmaceutical products containing related compounds.

Basic Information

Product Name	Benadryl n-Oxide Hydrochloride
CAS No.	13168-00-8
Molecular Formula	C17H22ClNO2
Molecular Weight	307.81 g/mol
Synonyms	Diphenhydramine N-Oxide Hydrochloride; N,N-Dimethyl-2-(diphenylmethoxy)ethylamine N-Oxide Hydrochloride; 2-(Benzhydryloxy)-N,N-dimethylethanamine N-Oxide Hydrochloride; DPH N-Oxide HCl; Benadryl N-Oxide HCl; Diphenhydramine N-Oxide HCl; Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, N-oxide, hydrochloride
EINECS	Contact for details

Quality Control

Our Benadryl n-Oxide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and conformity to stringent specifications. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.