Description

Insulin, Tri-Lys- is a chemically modified insulin derivative where three lysine residues are attached to the insulin molecule. This modification is critical for enhancing the stability and altering the pharmacokinetic profile of the hormone, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by biopharmaceutical companies and research institutions focused on developing next-generation therapeutic proteins and delivery systems. The compound, with CAS No. 12584-78-0, is essential for studies in diabetes treatment, peptide engineering, and metabolic disorder research.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel, long-acting insulin analogs for diabetes therapy.
• Bioconjugation Studies: Used as a model protein for developing and optimizing site-specific conjugation techniques with other molecules.
• Metabolic Research: Employed in preclinical studies to investigate the structure-activity relationship (SAR) of insulin and its effects on glucose metabolism.
• Drug Delivery System Development: Acts as a candidate for formulating sustained-release or controlled-release injectable depots.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC or MS methods.
• Peptide Chemistry Research: Provides a complex template for studying folding, stability, and chemical modification of polypeptides.

Basic Information

Product Name	Insulin, Tri-Lys-
CAS No.	12584-78-0
Molecular Formula	C264H402N72O79S6
Molecular Weight	~6058.0 g/mol
Synonyms	Tri-Lysine Insulin; Nε-Tri-Lysyl Insulin; Insulin Tri-Lysyl Derivative; Lys3-Insulin; Insulin Modified with Three Lysine Residues; Nε-(Tri-Lysyl)insulin; 12584-78-0; Insulin (Tri-Lys)
EINECS	Contact for details

Quality Control

Our Insulin, Tri-Lys- is produced and tested under strict quality management systems to ensure it meets the high standards required for pharmaceutical research. Each batch is characterized using advanced analytical techniques including HPLC, mass spectrometry, and peptide mapping. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 8.0%
Biological Activity	Assessed by in vitro assay (Contact for details)
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.