Description

(2R)-α,α,8α,8Aα-Tetramethyl-1,2,3,4,6,7,8,8A-Octahydronaphthalene-2α-Methanol is a high-purity, stereochemically defined intermediate of significant value in advanced organic synthesis. Its rigid, polycyclic structure makes it a versatile chiral building block for constructing complex molecules with precise three-dimensional architecture. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fragrance industries seeking to introduce specific stereocenters and lipophilic character into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for steroidal or terpenoid-based drug candidates.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where its specific stereochemistry can influence biological activity and environmental persistence.
• Fragrance & Flavor Chemistry: Acts as a starting material for synthesizing high-value odorants and flavor compounds with woody, amber, or musky notes, leveraging its decalin-derived skeleton.
• Material Science Research: Employed in the creation of specialty polymers and liquid crystals, where its rigid, hydrophobic core can impart desired physical properties.
• Asymmetric Catalysis Ligand Synthesis: Provides a scaffold for developing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Reference Standard: Supplied as a certified reference material (CRM) for analytical method development and quality control in regulatory and research laboratories.

Basic Information

Item	Detail
Product Name	(2R)-α,α,8α,8Aα-Tetramethyl-1,2,3,4,6,7,8,8A-Octahydronaphthalene-2α-Methanol
CAS No.	10219-71-3
Molecular Formula	C15H26O
Molecular Weight	222.37 g/mol
Synonyms	(2R)-2-Hydroxymethyl-1,1,4a,8a-tetramethyl-decahydronaphthalene; (2R)-2-(Hydroxymethyl)-1,1,4a,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene; (2R)-Decahydro-2-(hydroxymethyl)-1,1,4a,8a-tetramethylnaphthalene; (2R)-Ambrox; (2R)-Ambroxide precursor; (2R)-(-)-Ambrox; (2R)-Tetramethyloctahydronaphthalenemethanol
EINECS	Contact for details

Quality Control

Our (2R)-α,α,8α,8Aα-Tetramethyl-1,2,3,4,6,7,8,8A-Octahydronaphthalene-2α-Methanol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee (2R)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.