Description

o-Tolyl-Acetyl Chloride is a versatile and highly reactive organic intermediate, specifically an acid chloride derivative of o-tolylacetic acid. Its primary value lies in its role as a key acylating agent, enabling the efficient synthesis of amides, esters, and ketones under mild conditions. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to construct complex molecular frameworks.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs), particularly in the production of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents.
• Agrochemical Synthesis: Serves as a building block for manufacturing herbicides, fungicides, and plant growth regulators.
• Dyestuff and Pigment Production: Used in the creation of specialized azo dyes and organic pigments.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers and resins.
• Organic Synthesis Reagent: A fundamental reagent in academic and industrial R&D labs for introducing the o-tolylacetyl moiety into target molecules.
• Flavor and Fragrance Industry: Employed in the synthesis of certain aromatic compounds used in perfumery.

Basic Information

Product Name	o-Tolyl-Acetyl Chloride
CAS No.	10166-09-3
Molecular Formula	C9H9ClO
Molecular Weight	168.62 g/mol
Synonyms	2-Methylphenylacetyl chloride; (2-Methylphenyl)acetyl chloride; o-Tolylacetic acid chloride; 2-Methylbenzeneacetyl chloride; α-(o-Tolyl)acetyl chloride; NSC 406914; o-Methylphenylacetyl chloride
EINECS	233-418-6

Quality Control

Our o-Tolyl-Acetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We adhere to cGMP standards where applicable, and our quality management system is designed to meet the rigorous demands of the pharmaceutical and fine chemical industries. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC/HPLC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.