Description

Amifostine Disulfide is a key pharmaceutical intermediate and a stable oxidized derivative of the cytoprotective agent amifostine. This compound is critical for research and development in advanced therapeutic areas, particularly in mitigating the toxic side effects of chemotherapy and radiation therapy. It is primarily utilized by pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in oncology drug development and radioprotectant studies.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of amifostine and related cytoprotective agents.
• Oncology Research: Used in preclinical and clinical studies to investigate mechanisms of cellular protection against chemotherapeutic agents.
• Radioprotectant Development: A key material in formulating and testing compounds designed to protect healthy tissues during radiation therapy.
• Biochemical Research: Employed as a standard or reagent in studies of thiol biochemistry, oxidative stress, and redox signaling pathways.
• Reference Standard: Used in analytical laboratories for quality control and method development via HPLC or other chromatographic techniques.
• Drug Delivery Systems: Investigated for incorporation into novel delivery platforms to enhance stability and targeting of cytoprotective therapies.

Basic Information

Product Name	Amifostine Disulfide
CAS No.	10027-65-3
Molecular Formula	C5H15N2O3PS2
Molecular Weight	222.29 g/mol
Synonyms	WR-1065 Disulfide; Ethiofos Disulfide; S-2-(3-Aminopropylamino)ethylphosphorothioate Disulfide; Gammaphos Disulfide; Amifostine Dimer; NSC-689534 Disulfide; 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester Disulfide
EINECS	Contact for details

Quality Control

Our Amifostine Disulfide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with detailed HPLC, NMR, and mass spectrometry data are provided to guarantee traceability and consistent quality for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep the container tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.