Description

α-Methyl-D-Tyrosine is a synthetic, non-proteinogenic amino acid derivative that serves as a key chiral building block and biochemical research tool. Its primary value lies in its role as a specific inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and life science sectors, particularly for developing neuropharmacological agents and conducting metabolic pathway studies.

Application

• Pharmaceutical Intermediate: Critical chiral synthon for the research and development of novel central nervous system (CNS) active drugs and enzyme inhibitors.
• Biochemical Research: Used as a specific tool compound to inhibit catecholamine (dopamine, norepinephrine, epinephrine) synthesis in cellular and animal models.
• Metabolic Studies: Employed in neuroscience and endocrinology research to investigate tyrosine metabolism and related disorders.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Peptide Synthesis: Utilized as a modified tyrosine analog in the synthesis of specialized peptides for structure-activity relationship (SAR) studies.
• Enzymology: Applied in vitro to study the kinetics and mechanism of tyrosine hydroxylase and related aromatic amino acid hydroxylases.

Basic Information

Product Name	α-Methyl-D-Tyrosine
CAS No.	1991-86-2
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	D-α-Methyltyrosine; (R)-α-Methyltyrosine; (R)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; AMT; Metirosine impurity; H 44/68; NSC 113019; L-α-MPT (enantiomer)
EINECS	217-874-5

Quality Control

Our α-Methyl-D-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with in-house specifications. We support development projects with material suitable for research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic and should be kept under dry conditions to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.