Description

5-Ethynyl-2-Methylpyridine is a versatile pyridine derivative featuring both a methyl substituent and a terminal alkyne functional group. This unique bifunctional structure makes it a valuable high-purity building block for advanced organic synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, leveraging its pyridine core for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysts for cross-coupling reactions (e.g., Sonogashira coupling).
• Material Science Research: Employed in the synthesis of functionalized polymers, metal-organic frameworks (MOFs), and advanced organic electronic materials due to its reactive alkyne group.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags via click chemistry (azide-alkyne cycloaddition) for studying biological systems.
• Fine Chemical Production: Acts as a building block for various specialty and fine chemicals requiring a substituted pyridine scaffold.

Basic Information

Item	Detail
Product Name	5-Ethynyl-2-Methylpyridine
CAS No.	1945-85-3
Molecular Formula	C8H7N
Molecular Weight	117.15 g/mol
Synonyms	2-Methyl-5-ethynylpyridine; 5-Ethynyl-2-picoline; 2-Picoline, 5-ethynyl-; 2-Methyl-5-ethynylpyridine; 5-Ethynyl-2-methylpyridine; 2-Methyl-5-(ethynyl)pyridine; (5-Ethynyl-2-pyridinyl)methane
EINECS	Contact for details

Quality Control

We supply 5-Ethynyl-2-Methylpyridine in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥95.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.