Description

Itaconyl Chloride is a highly reactive acyl chloride derivative of itaconic acid, serving as a critical building block for advanced organic synthesis. Its primary value lies in introducing the itaconate moiety into target molecules, enabling the creation of specialized polymers, pharmaceuticals, and fine chemicals. This versatile intermediate is essential for R&D chemists and production engineers in the pharmaceutical, agrochemical, and specialty polymer industries seeking to develop novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: Key starting material for synthesizing active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring bioisosteric replacement or specific ester/amide functionalities.
• Polymer Chemistry: Monomer for producing specialized polyesters, polyamides, and coatings with enhanced durability, adhesion, or biodegradability profiles.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and plant growth regulators that benefit from the itaconate structure.
• Crosslinking Agent: Imparts crosslinking sites in resin and polymer systems to improve thermal stability and mechanical strength.
• Fine Chemical Production: Intermediate for synthesizing complex molecules used in flavors, fragrances, and advanced material science.
• Bioconjugation & Linker Chemistry: Useful in bioconjugation techniques for attaching molecules to proteins, peptides, or other biomolecules.

Basic Information

Product Name	Itaconyl Chloride
CAS No.	1931-60-8
Molecular Formula	C5H5ClO3
Molecular Weight	148.54 g/mol
Synonyms	2-Methylenesuccinyl chloride; Itaconoyl chloride; 2-Methylenebutanedioyl dichloride; 3-Carboxyacryloyl chloride; Itaconic acid dichloride; Itaconic dichloride; 2-Methylenesuccinic acid dichloride
EINECS	217-704-3

Quality Control

Our Itaconyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay (by titration or HPLC), identity confirmation (IR), and impurity profiling, to ensure it meets stringent specifications for purity and reactivity. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and highly volatile nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, well-ventilated place. Recommended storage temperature is 2-8°C. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Impurities (HPLC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.