Description

(3A,5A,12A)-3,12-Dihydroxy-Cholan-24-Oic Acid is a high-purity bile acid derivative, a key intermediate in the synthesis of pharmaceutical compounds. Its defined stereochemistry and functional groups make it a valuable chiral building block for research and production. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of ursodeoxycholic acid (UDCA) and other therapeutic bile acids.
• Biochemical Research: Used as a standard or reagent in studies of bile acid metabolism, liver function, and cholesterol homeostasis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Fine Chemical Synthesis: Employed as a chiral template or starting material for the production of complex organic molecules and active pharmaceutical ingredients (APIs).
• Metabolic Pathway Studies: Utilized in in-vitro and in-vivo research to investigate the role of bile acids in digestion and disease.

Basic Information

Product Name	(3A,5A,12A)-3,12-Dihydroxy-Cholan-24-Oic Acid
CAS No.	1912-55-6
Molecular Formula	C24H40O4
Molecular Weight	392.57 g/mol
Synonyms	3α,12α-Dihydroxy-5β-cholan-24-oic Acid; 3α,12α-Dihydroxy-5β-cholanic Acid; 12α-Hydroxylithocholic Acid; Chenodeoxycholic Acid Impurity; CDCA Impurity; 5β-Cholan-24-oic Acid-3α,12α-diol; 3α,12α-Dihydroxy-5β-cholanoic Acid
EINECS	217-636-5

Quality Control

Our (3A,5A,12A)-3,12-Dihydroxy-Cholan-24-Oic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical-grade intermediates. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.