Description

(2S,4R)-cis-4-Hydroxypiperidine-2-Carboxylic Acid CAS NO 1844-40-2 is a high-purity, stereochemically defined chiral piperidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in its unique bifunctional structure, featuring both a carboxylic acid and a hydroxyl group on a rigid piperidine scaffold, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly for developing novel active pharmaceutical ingredients (APIs) and complex chiral intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, receptor antagonists, and other bioactive molecules.
• Peptidomimetics Research: Used to construct constrained peptide analogs and foldamers due to its rigid, heterocyclic backbone.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Advanced Material Synthesis: Potential monomer for creating specialized polymers with specific stereochemical properties.

Basic Information

Product Name	(2S,4R)-cis-4-Hydroxypiperidine-2-Carboxylic Acid
CAS No.	1844-40-2
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(2S,4R)-4-Hydroxy-2-piperidinecarboxylic acid; cis-4-Hydroxy-D-proline; (2S,4R)-4-Hydroxypipecolic acid; (2S,4R)-Hpi; 4-Hydroxy-(2S,4R)-pipecolic acid; L-cis-4-Hydroxypipecolic acid; (2S,4R)-4-Hydroxy-pipecolate
EINECS	Contact for details

Quality Control

Our (2S,4R)-cis-4-Hydroxypiperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.