Description

[R-(R*,S*)]-α-[2-(Dimethylamino)-1-Methylethyl]-α-Phenylphenethyl Propionate Hydrochloride is a high-purity, complex organic compound primarily utilized as a critical intermediate in advanced pharmaceutical synthesis. Its value lies in its specific stereochemistry and functional groups, which are essential for constructing active pharmaceutical ingredients (APIs) with precise biological activity. This product is vital for research and development chemists and manufacturers in the pharmaceutical industry, particularly those developing central nervous system (CNS) agents, analgesics, or other specialized therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those targeting neurological pathways.
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new chemical entities (NCEs) and lead compounds.
• Process Chemistry: Serves as a critical starting material or intermediate in scale-up and commercial API manufacturing processes under GMP conditions.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control testing.
• Asymmetric Synthesis: Its defined stereochemistry makes it valuable for studies and applications in chiral synthesis and resolution.

Basic Information

Product Name	[R-(R*,S*)]-α-[2-(Dimethylamino)-1-Methylethyl]-α-Phenylphenethyl Propionate Hydrochloride
CAS No.	1596-70-9
Molecular Formula	C24H33NO3·HCl
Molecular Weight	419.99 g/mol
Synonyms	Propanoic acid, 2-methyl-, (2R,3S)-3-(dimethylamino)-1,2-diphenyl-2-butyl ester, hydrochloride; 2-Methylpropanoic acid (2R,3S)-3-(dimethylamino)-1,2-diphenyl-2-butyl ester hydrochloride; Lofexidine impurity C; Lofexidine related compound C; (2R,3S)-3-(Dimethylamino)-1,2-diphenyl-2-butyl isobutyrate hydrochloride; 1596-70-9; Lofexidine HCl Impurity C
EINECS	Contact for details

Quality Control

Our [R-(R*,S*)]-α-[2-(Dimethylamino)-1-Methylethyl]-α-Phenylphenethyl Propionate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with client specifications and relevant industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.