Description

6,11-Dihydro-11-Hydroxy Dothiepin is a key pharmaceutical intermediate and a significant metabolite of the tricyclic antidepressant dothiepin. This compound matters for its critical role in the synthesis and pharmacological study of active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in neuropharmacology and drug metabolism studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of tricyclic antidepressant APIs and related analogs.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and validation.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to understand the metabolic pathway of dothiepin.
• Biochemical Research: Serves as a tool compound in neuroscience research to investigate mechanisms of action and receptor binding profiles.
• Quality Control: Acts as an impurity standard for the HPLC/GC analysis of dothiepin and its finished dosage forms.

Basic Information

Product Name	6,11-Dihydro-11-Hydroxy Dothiepin
CAS No.	1531-85-7
Molecular Formula	C19H21NOS
Molecular Weight	311.44 g/mol
Synonyms	11-Hydroxydothiepin; 11-Hydroxy-6,11-dihydrodothiepin; Dothiepin Metabolite; Dothiepin Hydroxy Metabolite; 11-Hydroxydosulepin; Prothiaden Metabolite; 3-(11-Hydroxy-6H-dibenzo[b,e]thiepin-11-yl)-N,N-dimethylpropan-1-amine
EINECS	Contact for details

Quality Control

Our 6,11-Dihydro-11-Hydroxy Dothiepin is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.