Description

Difluoromethylphosphonic Acid Diethyl Ester is a high-value organophosphorus building block characterized by its reactive difluoromethylphosphonate group. This compound is essential for introducing the difluoromethylphosphonate moiety into target molecules, a key step in the synthesis of bioactive compounds and advanced materials. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of enzyme inhibitors, prodrugs, and other bioactive molecules, particularly those targeting metabolic pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides, pesticides, and plant growth regulators where the difluoromethyl group enhances stability and bioavailability.
• Ligand and Catalyst Preparation: Serves as a key starting material for creating specialized phosphonate-based ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying biological processes.
• Material Science Research: Utilized in the development of flame retardants, polymer modifiers, and specialty surfactants.
• Process Chemistry & Scale-up: Serves as a reliable building block for process optimization and the commercial-scale production of target active ingredients.

Basic Information

Product Name	Difluoromethylphosphonic Acid Diethyl Ester
CAS No.	1478-53-1
Molecular Formula	C5H11F2O3P
Molecular Weight	188.11 g/mol
Synonyms	Diethyl Difluoromethylphosphonate; (Diethoxyphosphinyl)difluoromethane; Difluoromethylphosphonic Acid Diethyl Ester; Diethyl (Difluoromethyl)phosphonate; EINECS 216-034-1; Phosphonic acid, difluoromethyl-, diethyl ester
EINECS	216-034-1

Quality Control

Our Difluoromethylphosphonic Acid Diethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizers. Recommended storage temperature is between 2°C and 25°C. The product is moisture-sensitive; keep container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.25 g/cm³
Refractive Index (n20D)	~1.380 - 1.390

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.