Description

3β,7β,14-Trihydroxy-5β-Card-20(22)-Enolide is a high-purity steroidal cardenolide compound, a key intermediate in the synthesis of various pharmaceutical agents. Its precise stereochemistry and functional groups make it a critical building block for producing potent cardiac glycosides and other bioactive molecules. This compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical suppliers focused on cardiovascular and oncology drug discovery.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor for cardiac glycosides like digoxin and digitoxin.
• Research & Development: Serves as a critical reference standard and starting material in medicinal chemistry for novel drug discovery programs.
• Biochemical Research: Used in studies investigating the mechanism of action of Na+/K+-ATPase inhibitors.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex steroidal derivatives with targeted biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3β,7β,14-Trihydroxy-5β-Card-20(22)-Enolide
CAS No.	1173-21-3
Molecular Formula	C₂₃H₃₄O₆
Molecular Weight	406.51 g/mol
Synonyms	3β,7β,14-Trihydroxy-5β-card-20(22)-enolide; 3β,7β,14-Trihydroxy-5β,14β-card-20(22)-enolide; 3β,7β,14-Trihydroxy-5β-card-20(22)-enolide (Digitoxigenin derivative); 14β,3β,7β-Trihydroxy-5β-card-20(22)-enolide; 3β,7β,14-Trihydroxy-5β-card-20(22)-enolide (IUPAC); 1173-21-3; Card-20(22)-enolide, 3,7,14-trihydroxy-, (3β,5β,7β)-; A key digitoxigenin intermediate.
EINECS	Contact for details

Quality Control

Our 3β,7β,14-Trihydroxy-5β-Card-20(22)-Enolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.