Description

Lachesine Hydrochloride CAS NO 1164-38-1 is a quaternary ammonium anticholinergic agent, primarily recognized for its pharmacological activity as a muscarinic acetylcholine receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its potential in modulating cholinergic pathways. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers in the ophthalmic, neurological, and gastrointestinal therapeutic areas, where precise control of parasympathetic nervous system activity is required.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced anticholinergic and antispasmodic drug candidates.
• Ophthalmic Research: Investigated for use in formulating cycloplegic and mydriatic agents to dilate pupils and paralyze accommodation for eye examinations or surgeries.
• Neurological Studies: Used in preclinical research to study the role of muscarinic receptors in conditions like Parkinson's disease, overactive bladder, and chronic obstructive pulmonary disease (COPD).
• Gastrointestinal Agent Development: Explored for potential in developing medications to treat peptic ulcers, irritable bowel syndrome (IBS), and other smooth muscle spasms.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and research laboratories for method development and validation.
• Biochemical Tool: Utilized in receptor binding assays and pharmacological studies to characterize subtype selectivity and potency of anticholinergic compounds.

Basic Information

Product Name	Lachesine Hydrochloride
CAS No.	1164-38-1
Molecular Formula	C21H28ClNO3 • HCl
Molecular Weight	422.37 g/mol
Synonyms	Benzydiol hydrochloride; (±)-2-(Diethylamino)ethyl α-phenyl-α-(2-thienyl)glycolate hydrochloride; Lachesine HCl; Lachesin hydrochloride; Thiphenamil hydrochloride (related compound); Antrenyl; α-Phenyl-α-2-thienylglycolic acid 2-diethylaminoethyl ester hydrochloride; 2-(Diethylamino)ethyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate hydrochloride
EINECS	Contact for details

Quality Control

Our Lachesine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-grade specifications suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.