Description

Tolazamide CAS NO 1156-19-0 is a second-generation sulfonylurea compound primarily recognized for its role as an oral hypoglycemic agent. This pharmaceutical active ingredient is critical for the management of non-insulin-dependent diabetes mellitus (NIDDM) by stimulating insulin secretion from pancreatic beta cells. It is essential for pharmaceutical manufacturers and research institutions developing and producing antidiabetic medications.

Application

• Pharmaceutical Active Ingredient: Primary use as the key component in oral antidiabetic tablets for the treatment of Type 2 diabetes.
• Clinical Research: Utilized in metabolic disorder studies and pharmacological research to investigate insulin secretion mechanisms.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development and validation.
• Drug Formulation Development: Employed in pre-formulation and formulation studies for developing sustained-release or combination drug products.
• Biochemical Research: Used in in-vitro studies to understand the interaction of sulfonylureas with ATP-sensitive potassium channels.

Basic Information

Product Name	Tolazamide
CAS No.	1156-19-0
Molecular Formula	C14H21N3O3S
Molecular Weight	311.40 g/mol
Synonyms	1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; Tolinase; Tolanase; N-[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide; Glycotron; Ronase; Diabewas; Diabuton; Tolisan
EINECS	214-571-6

Quality Control

Our Tolazamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities NMT 2.0% Any individual impurity NMT 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.