Description

Propyl Chloroformate is a versatile and highly reactive alkyl chloroformate ester, widely used as a key reagent in organic synthesis and pharmaceutical manufacturing. Its primary value lies in its ability to act as a propyloxycarbonylating agent, facilitating the introduction of the propyl carbamate protecting group and serving as an intermediate in the synthesis of more complex molecules. This compound is essential for R&D chemists and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries, where it is employed in peptide synthesis, polymer chemistry, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of various active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring a propyl carbamate moiety.
• Peptide Synthesis: Used as a reagent for the temporary protection of amino groups (as the N-propyloxycarbonyl, or Poc, group) during solid-phase and solution-phase peptide synthesis.
• Agrochemical Production: Serves as an intermediate in the manufacture of certain herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of polycarbonates, polyurethanes, and other specialty polymers.
• Chemical Derivatization: Employed in analytical chemistry to derivative alcohols, phenols, and amines for gas chromatography (GC) or HPLC analysis to improve detection.
• Organic Synthesis Reagent: Utilized in various carbonylation and esterification reactions to introduce the propyloxycarbonyl functional group.

Basic Information

Product Name	Propyl Chloroformate
CAS No.	109-61-5
Molecular Formula	C4H7ClO2
Molecular Weight	122.55 g/mol
Synonyms	Propyl Chloroformate; n-Propyl Chloroformate; Propyl Chlorocarbonate; Chloroformic Acid Propyl Ester; n-Propyl Chlorocarbonate; Propoxycarbonyl Chloride; Carbonochloridic Acid Propyl Ester
EINECS	203-687-7

Quality Control

Our Propyl Chloroformate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Each production lot undergoes comprehensive analytical testing, including assay by GC or titration and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity limits is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its highly volatile and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Acidity (as HCl)	≤ 0.5%
Density at 20°C	1.090 - 1.100 g/mL
Refractive Index (n20D)	1.403 - 1.413

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.