Alkylating Antineoplastic Agents

Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

2-Aziridinyl-5-(2-Hydroxyethylamino)-3,5-Bis(Carboethoxyamino)-1,4-Benzoquinone CAS NO 77280-56-9

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CAS No.:77280-56-9

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Content:99.90%

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(-)-1,1'-Dithiodiethylenebis[3-(2-Chloroethyl)-3-Nitrosourea] CAS NO 77456-14-5

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CAS No.:77456-14-5

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4-((Bis(2-Chloroethyl)Amino)Methyl)-2-Nitro-Phenol Hydrochloride CAS NO 77905-50-1

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CAS No.:77905-50-1

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Ethyl n-[Bis(2-Chloroethyl)Amino]Carbamate CAS NO 77944-95-7

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CAS No.:77944-95-7

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Diammine Platinum(Ii) Dilactate CAS NO 78022-86-3

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CAS No.:78022-86-3

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N,n-Bis(2-Chloroethyl)-1,3,2-Oxazaphosphonan-2-Amine CAS NO 78219-90-6

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CAS No.:78219-90-6

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3-Hydroxycyclophosphamide CAS NO 78336-02-4

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CAS No.:78336-02-4

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trans-5-Fluorocyclophosphamide CAS NO 78542-60-6

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CAS No.:78542-60-6

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